Friday, September 18, 2015

Blood Components & The ABO Blood Group System

American Red Cross




Blood Components

How can one donation help multiple people?

In modern medical treatments, patients may receive a pint of whole blood or just specific components of the blood needed to treat their particular condition. Up to four components can be derived from donated blood. This approach to treatment, referred to as blood component therapy, allows several patients to benefit from one pint of donated whole blood. The main transfusable blood components include:

Whole Blood

Whole blood contains red cells, white cells, and platelets (~45% of volume) suspended in plasma (~55% of volume).

Red cells

Red cells, or erythrocytes, carry oxygen from the lungs to your body’s tissue and take carbon dioxide back to your lungs to be exhaled.

Platelets

Platelets, or thrombocytes, are small, colorless cell fragments in the blood whose main function is to interact with clotting proteins to stop or prevent bleeding.

Plasma

Plasma is a fluid, composed of about 92% water, 7% vital proteins such as albumin, gamma globulin, anti- hemophilic factor, and other clotting factors, and 1% mineral salts, sugars, fats, hormones and vitamins.

Cryoprecipitated AHF

Cryoprecipitated Antihemophilic Factor (Cryo) is a portion of plasma rich in clotting factors, including Factor VIII and fibrinogen. It is prepared by freezing and then slowly thawing the frozen plasma.

Transformable Blood Components Summary


Whole Blood Red Blood Cells Platelets Plasma Cryoprecipitated AHF
COLOR OF THIS BLOOD COMPONENT
Red Red Colorless Yellowish White 
BLOOD COMPONENT SHELF LIFE
21 / 35  Days* Up to 42 Days* 5 Days 1 Year 1 Year
STORAGE CONDITIONS
Refrigerated Refrigerated Room temperature with constant agitation to prevent clumping Frozen Frozen
KEY USES OF THIS BLOOD TYPE
  • Trauma
  • Surgery
  • Trauma
  • Surgery
  • Anemia
  • Any blood loss
  • Blood disorders, such as sickle cell
  • Cancer treatments
  • Organ transplants
  • Surgery
  • Burn patients
  • Shock
  • Bleeding disorders
  • Hemophilia
  • Von Willebrand disease (most common hereditary coagulation abnormality)
  • Rich source of Fibrinogen
   * Shelf life of whole blood and red cells varies based on the type anticoagulant used.


Although all blood is made of the same basic elements, not all blood is alike. In fact, there are eight different common blood types, which are determined by the presence or absence of certain antigens – substances that can trigger an immune response if they are foreign to the body. Since some antigens can trigger a patient's immune system to attack the transfused blood, safe blood transfusions depend on careful blood typing and cross-matching.

The ABO Blood Group System

There are four major blood groups determined by the presence or absence of two antigens – A and B – on the surface of red blood cells:
  • Group A – has only the A antigen on red cells (and B antibody in the plasma)
  • Group B – has only the B antigen on red cells (and A antibody in the plasma)
  • Group AB – has both A and B antigens on red cells (but neither A nor B antibody in the plasma)
  • Group O – has neither A nor B antigens on red cells (but both A and B antibody are in the plasma)
There are very specific ways in which blood types must be matched for a safe transfusion. See the chart below: 
Blood type chart
Group O O Blood Type diagram linking blood types O Blood Type
A can donate red blood cells to A's and AB's A Blood Type A Blood Type
B can donate red blood cells to B's and AB's B Blood Type B Blood Type
Group AB can donate to other AB's but can receive from all others AB Blood Type AB Blood Type
In addition to the A and B antigens, there is a third antigen called the Rh factor, which can be either present (+) or absent ( – ). In general, Rh negative blood is given to Rh-negative patients, and Rh positive blood or Rh negative blood may be given to Rh positive patients.
  • The universal red cell donor has Type O negative blood type.
  • The universal plasma donor has Type AB blood type.

Blood Types and the Population

O positive is the most common blood type. Not all ethnic groups have the same mix of these blood types. Hispanic people, for example, have a relatively high number of O’s, while Asian people have a relatively high number of B’s. The mix of the different blood types in the U.S. population is:
Caucasians
African American
Hispanic
Asian
O +
37%
47%
53%
39%
O -
8%
4%
4%
1%
A +
33%
24%
29%
27%
A -
7%
2%
2%
0.5%
B +
9%
18%
9%
25%
B -
2%
1%
1%
0.4%
AB +
3%
4%
2%
7%
AB -
1%
0.3%
0.2%
0.1%
Some patients require a closer blood match than that provided by the ABO positive/negative blood typing. For example, sometimes if the donor and recipient are from the same ethnic background the chance of a reaction can be reduced. That’s why an African-American blood donation may be the best hope for the needs of patients with sickle cell disease, 98 percent of whom are of African-American descent.

How Is My Blood Type Determined?

It’s inherited. Like eye color, blood type is passed genetically from your parents. Whether your blood group is type A, B, AB or O is based on the blood types of your mother and father.
This chart shows the potential blood types you may inherit. 
Parent 1 AB AB AB AB B A A O O O
Parent 2 AB B A O B B A B A O
Possible
blood
type
of
child
O X X X X X X
A X X X X X X X
B X X X X X X X
AB X X X X
* Note: If you have questions about paternity testing or about blood group inheritance, your primary care physician should be able to provide you with an appropriate referral. Testing difficulties can cause exceptions to the above patterns. ABO blood typing is not sufficient to prove or disprove paternity or maternity.
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